|Application ||WB, E|
|Other Accession||NP_004496.1, 9098|
|Calculated MW||158658 Da|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 6, 18.104.22.168, Deubiquitinating enzyme 6, Proto-oncogene TRE-2, Ubiquitin thioesterase 6, Ubiquitin-specific-processing protease 6, USP6, HRP1, TRE2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||USP6 / TRE2 / TRE17 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.|
|Cellular Location||Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton|
|Tissue Location||Testis specific. Expressed in various cancer cell lines.|
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The Tre2 (USP6) oncogene is a hominoid-specific gene. Paulding CA, Ruvolo M, Haber DA. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2507-11. PMID: 12604796
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