LAX Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q8IWV1 |
Other Accession | NP_060243.2, NP_001129662.1, 54900 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 44085 Da |
Gene ID | 54900 |
---|---|
Other Names | Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX, LAX1, LAX |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LAX Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LAX1 |
---|---|
Synonyms | LAX |
Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
Cellular Location | Cell membrane; Single-pass type III membrane protein |
Tissue Location | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported isoforms.
References
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. Zhu M, Janssen E, Leung K, Zhang W. J Biol Chem. 2002 Nov 29;277(48):46151-8. PMID: 12359715
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