|Application ||WB, E|
|Other Accession||NP_004747.1, 9253, 18223 (mouse)|
|Calculated MW||64891 Da|
|Other Names||Numb-like protein, Numb-related protein, Numb-R, NUMBL|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUMBL Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.|
|Cellular Location||Cytoplasm. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.|
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Provided below are standard protocols that you may find useful for product applications.
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Nature. 2002 Oct 31;419(6910):929-34. PMID: 12410312
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