|Application ||WB, E|
|Other Accession||NP_036528.1, 23612, 27280 (mouse)|
|Calculated MW||13891 Da|
|Other Names||Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homolog 1, PHLDA3, TIH1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHLDA3 / TIH1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Widely expressed with lowest expression in liver and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R, Tycko B. Mamm Genome. 1999 Dec;10(12):1150-9. PMID: 10594239
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