|Application ||WB, E|
|Other Accession||NP_036528.1, 23612, 27280 (mouse)|
|Calculated MW||13891 Da|
|Other Names||Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homolog 1, PHLDA3, TIH1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHLDA3 / TIH1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Widely expressed with lowest expression in liver and spleen.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R, Tycko B. Mamm Genome. 1999 Dec;10(12):1150-9. PMID: 10594239
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