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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > INADL / PATJ Antibody (N-Term)
INADL / PATJ Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q8NI35 |
| Other Accession | NP_795352.2, 10207 |
| Reactivity | Human |
| Predicted | Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 196368 Da |
| Other Names | InaD-like protein, Inadl protein, hINADL, Pals1-associated tight junction protein, Protein associated to tight junctions, INADL, PATJ |
|---|---|
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | INADL / PATJ Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PATJ {ECO:0000303|PubMed:22006950, ECO:0000312|HGNC:HGNC:28881} |
|---|---|
| Function | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). |
| Cellular Location | Cell junction, tight junction. Apical cell membrane; Peripheral membrane protein. Cytoplasm, perinuclear region. Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (PubMed:11964389). Localized in the paranodal region of myelinating Schwann cells (By similarity) Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7} |
| Tissue Location | Expressed in renal tubules (at protein level) (PubMed:19755384). Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster. Philipp S, Flockerzi V. FEBS Lett. 1997 Aug 18;413(2):243-8. PMID: 9280290
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$ 341.00
Cat# AF2388a
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