|Application ||IHC, E|
|Other Accession||NP_795352.2, 10207|
|Predicted||Pig, Dog, Cow|
|Calculated MW||196368 Da|
|Other Names||InaD-like protein, Inadl protein, hINADL, Pals1-associated tight junction protein, Protein associated to tight junctions, INADL, PATJ|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INADL / PATJ Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.|
|Cellular Location||Membrane. Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear region Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells. Also found at the apical plasma membrane.|
|Tissue Location||Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster. Philipp S, Flockerzi V. FEBS Lett. 1997 Aug 18;413(2):243-8. PMID: 9280290
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