|Application ||IHC, E|
|Other Accession||NP_079119.3, 79901|
|Predicted||Pig, Dog, Cow|
|Calculated MW||31641 Da|
|Other Names||Cytochrome b reductase 1, 1.-.-.-, Duodenal cytochrome b, Ferric-chelate reductase 3, CYBRD1, DCYTB, FRRS3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Cytochrome b reductase 1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform 1 (NP_079119.3) only.
Duodenal ascorbate and ferric reductase in human iron deficiency. Atanasova BD, Li AC, Bjarnason I, Tzatchev KN, Simpson RJ. Am J Clin Nutr. 2005 Jan;81(1):130-3. PMID: 15640471
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