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Cytochrome b reductase 1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q53TN4 |
| Other Accession | NP_079119.3, 79901 |
| Reactivity | Human, Mouse |
| Predicted | Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 31641 Da |
| Gene ID | 79901 |
|---|---|
| Other Names | Cytochrome b reductase 1, 1.-.-.-, Duodenal cytochrome b, Ferric-chelate reductase 3, CYBRD1, DCYTB, FRRS3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Cytochrome b reductase 1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYBRD1 (HGNC:20797) |
|---|---|
| Function | Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro- L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized at the brush border of duodenal cells. |
| Tissue Location | Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise isoform 1 (NP_079119.3) only.
References
Duodenal ascorbate and ferric reductase in human iron deficiency. Atanasova BD, Li AC, Bjarnason I, Tzatchev KN, Simpson RJ. Am J Clin Nutr. 2005 Jan;81(1):130-3. PMID: 15640471
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