|Application ||WB, E|
|Other Accession||NP_038474.1, NP_001138597.1, 23608|
|Calculated MW||53349 Da|
|Other Names||E3 ubiquitin-protein ligase makorin-1, 6.3.2.-, RING finger protein 61, MKRN1, RNF61|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Makorin Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This antibody may cross react with MKRN4 (52.9kDa).
Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. Kim JH, Park SM, Kang MR, Oh SY, Lee TH, Muller MT, Chung IK. Genes Dev. 2005 Apr 1;19(7):776-81. PMID: 15805468
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.