|Application ||IHC, E|
|Other Accession||NP_055211.2, NP_542198.2, 27072|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||98566 Da|
|Other Names||Vacuolar protein sorting-associated protein 41 homolog, S53, VPS41|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VPS41 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE- mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660).|
|Cellular Location||Endosome membrane. Late endosome Lysosome. Golgi apparatus, trans- Golgi network. Early endosome. Cytoplasmic vesicle, clathrin- coated vesicle|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_055211.2 and NP_542198.2)
hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif. McVey Ward D, Radisky D, Scullion MA, Tuttle MS, Vaughn M, Kaplan J. Exp Cell Res. 2001 Jul 1;267(1):126-34. PMID: 11412045
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