|Application ||IHC, E|
|Other Accession||NP_149094.3, 85415|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||76993 Da|
|Other Names||Rhophilin-2, 76 kDa RhoB effector protein, GTP-Rho-binding protein 2, p76RBE, RHPN2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Rhophilin 2 (Internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver|
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Provided below are standard protocols that you may find useful for product applications.
The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD. J Biol Chem. 2002 Nov 15;277(46):43924-32. PMID: 12221077
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