|Other Accession||NP_055747.1, 22871|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||93835 Da|
|Other Names||Neuroligin-1, NLGN1, KIAA1070|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Neuroligin 1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity).|
|Tissue Location||Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.|
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Provided below are standard protocols that you may find useful for product applications.
Control of Excitatory and Inhibitory Synapse Formation by Neuroligins. Chih B, Engelman H, Scheiffele P. Science. 2005 Jan 27; [Epub ahead of print] PMID: 15681343
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