|Application ||IHC, E|
|Other Accession||NP_000852.1, NP_001091681.1, NP_001091682.1, NP_001091683.1, 3269, 15465 (mouse), 24448 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||55784 Da|
|Other Names||Histamine H1 receptor, H1R, HH1R, HRH1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Histamine Receptor H1 (C Term) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Variants (NP_000852.1; NP_001091681.1; NP_001091682.1; NP_001091683.1) encode the same protein.
Beta(2)-adrenergic receptor-mediated histamine H(1) receptor down-regulation: another possible advantage of beta(2) agonists in asthmatic therapy. Kawakami N, Miyoshi K, Horio S, Fukui H. J Pharmacol Sci. 2004 Apr;94(4):449-58. PMID: 15107586
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