|Application ||IHC, IF, E|
|Other Accession||NP_071640.1, NP_001124527.1, 3274|
|Predicted||Human, Mouse, Dog|
|Calculated MW||40098 Da|
|Other Names||Histamine H2 receptor, H2R, HH2R, Gastric receptor I, HRH2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Histamine Receptor H2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms.
Histamine: its novel role as an endogenous regulator of Con A-dependent T cell proliferation. Nakane H, Sonobe Y, Watanabe T, Nakano K. Inflamm Res. 2004 Jul;53(7):324-8. Epub 2004 Jun 25. PMID: 15241568
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