|Application ||IHC, E|
|Other Accession||NP_000426.2, 4854|
|Predicted||Human, Mouse, Rat|
|Calculated MW||243631 Da|
|Other Names||Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NOTCH3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitously expressed in fetal and adult tissues|
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Provided below are standard protocols that you may find useful for product applications.
Notch3 signaling initiates choroid plexus tumor formation. Dang L, Fan X, Chaudhry A, Wang M, Gaiano N, Eberhart CG. Oncogene. 2005 Sep 26; [Epub ahead of print] PMID: 16186803
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