|Application ||FC, E|
|Other Accession||NP_071765.2, 64221|
|Calculated MW||148209 Da|
|Other Names||Roundabout homolog 3, Roundabout-like protein 3, ROBO3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ROBO3 (internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rub U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Ya Science. 2004 Jun 4;304(5676):1509-13. Epub 2004 Apr 22. PMID: 15105459
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