|Other Accession||NP_000788.2, 1815|
|Calculated MW||48361 Da|
|Other Names||D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor, DRD4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Dopamine receptor D4 / DRD4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Li D, Sham PC, Owen MJ, He L. Hum Mol Genet. 2006 Jul 15;15(14):2276-84. Epub 2006 Jun 14. PMID: 16774975
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