|Other Accession||NP_000788.2, 1815|
|Calculated MW||48361 Da|
|Other Names||D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor, DRD4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Dopamine receptor D4 / DRD4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.|
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Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Li D, Sham PC, Owen MJ, He L. Hum Mol Genet. 2006 Jul 15;15(14):2276-84. Epub 2006 Jun 14. PMID: 16774975
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