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CHD5 Antibody (internal region)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TDI0
Other Accession NP_056372.1, 26038, 269610 (mouse)
Predicted Human, Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 223050 Da
Additional Information
Gene ID 26038
Other Names Chromodomain-helicase-DNA-binding protein 5, CHD-5,, ATP-dependent helicase CHD5, CHD5 {ECO:0000312|EMBL:AAL98962.1}, KIAA0444
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHD5 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHD5 {ECO:0000312|EMBL:AAL98962.1}
Synonyms KIAA0444
Function Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
Cellular Location Nucleus. Note=Associates with heterochromatin.
Tissue Location Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis
Research Areas
Citations (0)

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CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system. Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM. Oncogene. 2003 Feb 20;22(7):1002-11. PMID: 12592387 [PubMed - indexed for MEDLINE

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$ 325.00
Cat# AF2571a
(40 western blots)
Availability: 7-10 days
Bulk Size
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