|Other Accession||NP_116011.1, 84708|
|Calculated MW||80629 Da|
|Other Names||E3 ubiquitin-protein ligase LNX, 6.3.2.-, Ligand of Numb-protein X 1, Numb-binding protein 1, PDZ domain-containing RING finger protein 2, LNX1, LNX, PDZRN2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LNX1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.|
|Tissue Location||Expressed in heart, placenta, kidney, pancreas and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y. Int J Biochem Cell Biol. 2005 Nov;37(11):2273-83. Epub 2005 Apr 11. PMID: 16002321
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