|Application ||WB, E|
|Other Accession||NP_775259.1, NP_001028748.1, 146862, 217012 (mouse), 303373 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||103733 Da|
|Other Names||Protein unc-45 homolog B, Unc-45B, SMUNC45, UNC45B, CMYA4, UNC45|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UNC45B Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.|
|Cellular Location||Cytoplasm, cytosol.|
|Tissue Location||Expressed in eye lens tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_775259.1and NP_001028748.1).
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. Landsverk ML, Li S, Hutagalung AH, Najafov A, Hoppe T, Barral JM, Epstein HF. J Cell Biol. 2007 Apr 23;177(2):205-10. Epub 2007 Apr 16. PMID: 17438072
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