|Other Accession||NP_006366.2, NP_872114.1, 10495|
|Calculated MW||70082 Da|
|Other Names||Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX, Hydroquinone [NADH] oxidase, 1.-.-.-, Protein disulfide-thiol oxidoreductase, 1.-.-.-, ENOX2, COVA1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENOX2 / APK1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.|
|Cellular Location||Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated|
|Tissue Location||Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_006366.2; NP_872114.1).
tNOX is both necessary and sufficient as a ular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate. Chueh PJ, Wu LY, Morre DM, Morre DJ. Biofactors. 2004;20(4):235-49. PMID: 15706060
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