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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > MAP3K7IP3 (aa 274 to 285) Antibody (internal region)
MAP3K7IP3 (aa 274 to 285) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8N5C8 |
| Other Accession | NP_690000.2, 257397, 66724 (mouse) |
| Predicted | Human, Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 78653 Da |
| Gene ID | 257397 |
|---|---|
| Other Names | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TAB-3, TGF-beta-activated kinase 1-binding protein 3, TAB3, MAP3K7IP3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAP3K7IP3 (aa 274 to 285) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TAB3 {ECO:0000303|PubMed:14633987, ECO:0000312|HGNC:HGNC:30681} |
|---|---|
| Function | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). |
| Tissue Location | Widely expressed. Constitutively overexpressed in certain tumor tissues. [Isoform 2]: Minor transcript. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H. Mol Cell. 2007 Jun 8;26(5):689-702. PMID: 17560374
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$ 216.00
Cat# AF2634a
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