|Other Accession||NP_690000.2, 257397, 66724 (mouse)|
|Calculated MW||78683 Da|
|Other Names||TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TAB-3, TGF-beta-activated kinase 1-binding protein 3, TAB3, MAP3K7IP3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAP3K7IP3 (aa 274 to 285) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.|
|Tissue Location||Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H. Mol Cell. 2007 Jun 8;26(5):689-702. PMID: 17560374
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