|Application ||WB, E|
|Other Accession||NP_001456.3, NP_955367.1, NP_001230022.1, 2533|
|Calculated MW||85387 Da|
|Other Names||FYN-binding protein, Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein, FYB, SLAP130|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FYB Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise all reported isoforms (NP_001456.3; NP_955367.1; NP_001230022.1).
Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1. Medeiros RB, Burbach BJ, Mueller KL, Srivastava R, Moon JJ, Highfill S, Peterson EJ, Shimizu Y. Science. 2007 May 4;316(5825):754-8. PMID: 17478723
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