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CCBL1 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q16773 |
| Other Accession | NP_004050.3, NP_001116144.1, 883 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 47875 Da |
| Gene ID | 883 |
|---|---|
| Other Names | Kynurenine--oxoglutarate transaminase 1, 2.6.1.7, Cysteine-S-conjugate beta-lyase, 4.4.1.13, Glutamine transaminase K, GTK, Glutamine--phenylpyruvate transaminase, 2.6.1.64, Kynurenine aminotransferase I, KATI, Kynurenine--oxoglutarate transaminase I, CCBL1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCBL1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KYAT1 (HGNC:1564) |
|---|---|
| Synonyms | CCBL1 |
| Function | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). |
| Cellular Location | Cytoplasm, cytosol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_004050.3; NP_001116144.1)
References
The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants. Cooper AJ. Neurochem Int. 2004 Jun;44(8):557-77. PMID: 15016471
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