|Application ||WB, E|
|Other Accession||NP_060244.2, 54901, 68916 (mouse), 361243 (rat)|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||65111 Da|
|Other Names||Threonylcarbamoyladenosine tRNA methylthiotransferase, 220.127.116.11, CDK5 regulatory subunit-associated protein 1-like 1, tRNA-t(6)A37 methylthiotransferase, CDKAL1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDKAL1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum|
|Tissue Location||Expressed in pancreatic islets.|
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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD Science. 2007 Jun 1;316(5829):1336-41. PMID: 17463249
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