|Other Accession||NP_065843.3, 57552, 320024 (mouse)|
|Predicted||Human, Mouse, Dog|
|Calculated MW||45808 Da|
|Other Names||Neutral cholesterol ester hydrolase 1, NCEH, 3.1.1.-, Arylacetamide deacetylase-like 1, NCEH1, AADACL1, KIAA1363|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AADACL1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.|
|Cellular Location||Membrane; Single-pass type II membrane protein. Microsome|
|Tissue Location||Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chiang KP, Niessen S, Saghatelian A, Cravatt BF. Chem Biol. 2006 Oct;13(10):1041-50. PMID: 17052608
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