|Other Accession||NP_009000.2, 11145, 225845 (mouse), 24913 (rat)|
|Predicted||Human, Mouse, Rat, Cow|
|Calculated MW||17937 Da|
|Other Names||HRAS-like suppressor 3, HRSL3, 184.108.40.206, 220.127.116.11, Adipose-specific phospholipase A2, AdPLA, Group XVI phospholipase A1/A2, H-rev 107 protein homolog, HRAS-like suppressor 1, HREV107-1, HREV107-3, Renal carcinoma antigen NY-REN-65, PLA2G16, HRASLS3, HREV107|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HRASLS3 / HREV107-3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down- regulated in some ovarian carcinomas and testicular germ cell tumors.|
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Reported variants represent identical protein:NP_009000.2 and NP_001121675.1).
H-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signaling. Nazarenko I, Kristiansen G, Fonfara S, Guenther R, Gieseler C, Kemmner W, Schafer R, Petersen I, Sers C. Am J Pathol. 2006 Oct;169(4):1427-39. PMID: 17003497
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