|Application ||WB, E|
|Other Accession||NP_003079.1, 6624|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||54530 Da|
|Other Names||Fascin, 55 kDa actin-bundling protein, Singed-like protein, p55, FSCN1, FAN1, HSN, SNL|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FSCN1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAN1, HSN, SNL|
|Function||Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol|
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Provided below are standard protocols that you may find useful for product applications.
Role of fascin in filopodial protrusion. Vignjevic D, Kojima S, Aratyn Y, Danciu O, Svitkina T, Borisy GG. J Biol. 2006 Sep 11;174(6):863-75. PMID: 16966425
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