OCT6 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q03052 |
Other Accession | NP_002690.3, 5453 |
Reactivity | Human |
Predicted | Mouse, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 45496 Da |
Gene ID | 5453 |
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Other Names | POU domain, class 3, transcription factor 1, Octamer-binding protein 6, Oct-6, Octamer-binding transcription factor 6, OTF-6, POU domain transcription factor SCIP, POU3F1, OCT6, OTF6 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | OCT6 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | POU3F1 |
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Synonyms | OCT6, OTF6 |
Function | Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P21952}. |
Tissue Location | Expressed in embryonal stem cells and in the developing brain |
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Provided below are standard protocols that you may find useful for product applications.
References
Control of myelination in Schwann cells: a Krox20 cis-regulatory element integrates Oct6, Brn2 and Sox10 activities. Ghislain J, Charnay P. EMBO Rep. 2006 Jan;7(1):52-8. PMID: 16311519
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