|Other Accession||NP_000028.3, NP_065208.2, NP_065209.2, NP_065210.2, NP_065211.2, NP_065213.2, 286, 11733 (mouse), 306570 (rat)|
|Predicted||Human, Mouse, Rat, Cow|
|Calculated MW||206265 Da|
|Other Names||Ankyrin-1, ANK-1, Ankyrin-R, Erythrocyte ankyrin, ANK1, ANK|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Ankyrin 1 / ANK1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.|
|Cellular Location||Isoform Er1: Cytoplasm, cytoskeleton. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane Isoform Mu18: Sarcoplasmic reticulum Isoform Mu20: Sarcoplasmic reticulum|
|Tissue Location||Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform 3 (NP_000028.3) and isoform 5 (NP_065211.2).
Functional links between membrane transport and the spectrin cytoskeleton. Dubreuil RR. J Membr Biol. 2006;211(3):151-61. Epub 2006 Nov 7. Review. PMID: 17091212
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