|Application ||IHC, E|
|Other Accession||NP_059130.2, NP_787954.1, 53905|
|Calculated MW||177235 Da|
|Other Names||Dual oxidase 1, 1.11.1.-, 22.214.171.124, Large NOX 1, Long NOX 1, NADPH thyroid oxidase 1, Thyroid oxidase 1, DUOX1, DUOX, LNOX1, THOX1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Dual oxidase 1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DUOX, LNOX1, THOX1|
|Function||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|
|Cellular Location||Apical cell membrane; Multi- pass membrane protein. Note=Localizes to the apical membrane of epithelial cells|
|Tissue Location||Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_059130.2 ; NP_787954.1) which are identical;
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R. FEBS Lett. 2005 Aug 29;579(21):4911-7. PMID: 16111680
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