|Other Accession||NP_057700.3, 51314|
|Calculated MW||67270 Da|
|Other Names||Thioredoxin domain-containing protein 3, NM23-H8, NME/NM23 family member 8, Spermatid-specific thioredoxin-2, Sptrx-2, NME8, SPTRX2, TXNDC3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TXNDC3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.|
|Tissue Location||Testis-specific. Expressed only in primary spermatocytes and round spermatids.|
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A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. Duriez B, Duquesnoy P, Escudier E, Bridoux AM, Escalier D, Rayet I, Marcos E, Vojtek AM, Bercher JF, Amselem S. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3336-41. Epub 2007 Feb 20. Erratum. PMID: 17360648
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