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TXNDC3 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8N427 |
| Other Accession | NP_057700.3, 51314 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 67270 Da |
| Gene ID | 51314 |
|---|---|
| Other Names | Thioredoxin domain-containing protein 3, NM23-H8, NME/NM23 family member 8, Spermatid-specific thioredoxin-2, Sptrx-2, NME8, SPTRX2, TXNDC3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TXNDC3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NME8 (HGNC:16473) |
|---|---|
| Synonyms | SPTRX2, TXNDC3 |
| Function | Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. In vitro, it has neither nucleoside diphosphate kinase (NDPK) activity nor reducing activity on disulfide bonds (PubMed:11737268). Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair (PubMed:16313181). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Testis-specific. Expressed only in primary spermatocytes and round spermatids. |
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Provided below are standard protocols that you may find useful for product applications.
References
A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. Duriez B, Duquesnoy P, Escudier E, Bridoux AM, Escalier D, Rayet I, Marcos E, Vojtek AM, Bercher JF, Amselem S. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3336-41. Epub 2007 Feb 20. Erratum. PMID: 17360648
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