|Other Accession||NP_001453.1, 2358|
|Calculated MW||38964 Da|
|Other Names||N-formyl peptide receptor 2, FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP, FPR2, FPRH1, FPRL1, LXA4R|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FPRL1 (aa13-26) Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FPRH1, FPRL1, LXA4R|
|Function||Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001005738.1 and NP_001453.1.
The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases. Mitchell D, O'Meara SJ, Gaffney A, Crean JK, Kinsella BT, Godson C. J Biol Chem. 2007 May 25;282(21):15606-18. Epub 2007 Apr 2. PMID: 17403678
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