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SLC22A17 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8WUG5 |
| Other Accession | NP_065105.2, NP_057693.3, 51310, 59049 (mouse), 305886 (rat) |
| Predicted | Human, Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 68619 Da |
| Gene ID | 51310 |
|---|---|
| Other Names | Solute carrier family 22 member 17, 24p3 receptor, 24p3R, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, NgalR, SLC22A17, BOCT, BOIT |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC22A17 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC22A17 |
|---|---|
| Synonyms | BOCT, BOIT |
| Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized |
| Tissue Location | Expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms NP_065105.2 and NP_057693.3).
References
A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Devireddy LR, Gazin C, Zhu X, Green MR. Cell. 2005 Dec 29;123(7):1293-305. PMID: 16377569
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