|Other Accession||NP_065105.2, NP_057693.3, 51310, 59049 (mouse), 305886 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||57686 Da|
|Other Names||Solute carrier family 22 member 17, 24p3 receptor, 24p3R, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, NgalR, SLC22A17, BOCT, BOIT|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC22A17 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms NP_065105.2 and NP_057693.3).
A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Devireddy LR, Gazin C, Zhu X, Green MR. Cell. 2005 Dec 29;123(7):1293-305. PMID: 16377569
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