|Application ||IHC, E|
|Other Accession||NP_859529.2, 338557, 107221 (mouse), 294075 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||42241 Da|
|Other Names||Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, Omega-3 fatty acid receptor 1, FFAR4, GPR120, GPR129, O3FAR1, PGR4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR120 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR120, GPR129, O3FAR1, PGR4|
|Function||Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Colocalized with ARRB2 following DHA treatment.|
|Tissue Location||Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The regulation of adipogenesis through GPR120. Gotoh C, Hong YH, Iga T, Hishikawa D, Suzuki Y, Song SH, Choi KC, Adachi T, Hirasawa A, Tsujimoto G, Sasaki S, Roh SG. Biochem Biophys Res Commun. 2007 Mar 9;354(2):591-7. Epub 2007 Jan 16. PMID: 17250804
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