|Other Accession||NP_006191.2, 5125|
|Calculated MW||206942 Da|
|Other Names||Proprotein convertase subtilisin/kexin type 5, 3.4.21.-, Proprotein convertase 5, PC5, Proprotein convertase 6, PC6, hPC6, Subtilisin/kexin-like protease PC5, PCSK5, PC5, PC6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PCSK5 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins.|
|Cellular Location||Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway.|
|Tissue Location||Expressed in T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Hepatic proprotein convertases modulate HDL metabolism Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ Cell Metab. 2007 Aug;6(2):129-36 PMID: 17681148
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