PCSK5 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q92824 |
Other Accession | NP_006191.2, 5125 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 206942 Da |
Gene ID | 5125 |
---|---|
Other Names | Proprotein convertase subtilisin/kexin type 5, 3.4.21.-, Proprotein convertase 5, PC5, Proprotein convertase 6, PC6, hPC6, Subtilisin/kexin-like protease PC5, PCSK5, PC5, PC6 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PCSK5 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PCSK5 |
---|---|
Synonyms | PC5, PC6 |
Function | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. |
Cellular Location | [Isoform PC6A]: Secreted. Note=Secreted through the regulated secretory pathway. |
Tissue Location | Expressed in T-lymphocytes. |
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Provided below are standard protocols that you may find useful for product applications.
References
Hepatic proprotein convertases modulate HDL metabolism Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ Cell Metab. 2007 Aug;6(2):129-36 PMID: 17681148
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