|Other Accession||NP_006191.2, 5125|
|Calculated MW||206942 Da|
|Other Names||Proprotein convertase subtilisin/kexin type 5, 3.4.21.-, Proprotein convertase 5, PC5, Proprotein convertase 6, PC6, hPC6, Subtilisin/kexin-like protease PC5, PCSK5, PC5, PC6|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PCSK5 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins.|
|Cellular Location||Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway.|
|Tissue Location||Expressed in T-lymphocytes.|
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Hepatic proprotein convertases modulate HDL metabolism Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ Cell Metab. 2007 Aug;6(2):129-36 PMID: 17681148
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