|Other Accession||NP_001019831.2, NP_003938.1, NP_008995.2, 8997, 545156 (mouse), 84009 (rat)|
|Predicted||Human, Mouse, Rat, Cow|
|Calculated MW||340174 Da|
|Other Names||Kalirin, 220.127.116.11, Huntingtin-associated protein-interacting protein, Protein Duo, Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, KALRN, DUET, DUO, HAPIP, TRAD|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KALRN Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Note=Associated with the cytoskeleton|
|Tissue Location||Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms NP_001019831.2 and NP_003938.1.
Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines. Xie Z, Srivastava DP, Photowala H, Kai L, Cahill ME, Woolfrey KM, Shum CY, Surmeier DJ, Penzes P. Neuron. 2007 Nov 21;56(4):640-56. PMID: 18031682
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