|Application ||WB, E|
|Other Accession||NP_079470.1, 80271|
|Calculated MW||75207 Da|
|Other Names||Inositol-trisphosphate 3-kinase C, 220.127.116.11, Inositol 1, 4, 5-trisphosphate 3-kinase C, IP3 3-kinase C, IP3K C, InsP 3-kinase C, ITPKC, IP3KC|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IP3KC Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity|
|Tissue Location||Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain|
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ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Onouchi Y, Gunji T, Burns JC, Shimizu C, Newburger JW, Yashiro M, Nakamura Y, Yanagawa H, Wakui K, Fukushima Y, Kishi F, Hamamoto K, Terai M, Sato Y, Ouchi K, Saji T, Nariai A, Kaburagi Y, Yoshikawa T, Suzuki K, Tanaka T, Nagai T, Cho H, Fujino A, Sekine Nat Genet. 2008 Jan;40(1):35-42. Epub 2007 Dec 16. PMID: 18084290
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