|Application ||WB, E|
|Other Accession||NP_478136.1, 114907, 67731 (mouse), 171043 (rat)|
|Predicted||Rat, Pig, Cow|
|Calculated MW||41637 Da|
|Other Names||F-box only protein 32, Atrogin-1, Muscle atrophy F-box protein, MAFbx, FBXO32|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXO32 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and the nucleus|
|Tissue Location||Specifically expressed in cardiac and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoform 1 (NP_478136.1).
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH. J Clin Invest. 2007 Dec;117(12):3940-51. PMID: 17992259
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