|Other Accession||NP_006693.3, 10908, 50767 (mouse)|
|Calculated MW||149995 Da|
|Other Names||Neuropathy target esterase, 18.104.22.168, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NTE Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment|
|Tissue Location||Expressed in brain, placenta, kidney, neuron and skeletal muscle.|
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Neuropathy target esterase gene mutations cause motor neuron disease. Rainier S, Bui M, Mark E, Thomas D, Tokarz D, Ming L, Delaney C, Richardson
RJ, Albers JW, Matsunami N, Stevens J, Coon H, Leppert M, Fink JK. Am J Hum Genet. 2008 Mar;82(3):780-5. PMID: 18313024
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