|Application ||WB, E|
|Other Accession||NP_060712.2, 55244|
|Calculated MW||61922 Da|
|Other Names||Multidrug and toxin extrusion protein 1, MATE-1, hMATE-1, Solute carrier family 47 member 1, SLC47A1, MATE1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC47A1 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Predominantly localized at the plasma membrane but also found in intracellular organelles|
|Tissue Location||Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).|
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Provided below are standard protocols that you may find useful for product applications.
Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. Chen Y, Zhang S, Sorani M, Giacomini KM. J. Pharmacol. Exp. Ther. 2007 Aug 322 (2): 695-700. PMID: 17495125
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