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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > PEPT2 Antibody (C-Term)
PEPT2 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q16348 |
| Other Accession | NP_066568.2, 6565 |
| Predicted | Human, Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 81783 Da |
| Gene ID | 6565 |
|---|---|
| Other Names | Solute carrier family 15 member 2, Kidney H(+)/peptide cotransporter, Oligopeptide transporter, kidney isoform, Peptide transporter 2, SLC15A2, PEPT2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PEPT2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC15A2 (HGNC:10921) |
|---|---|
| Function | Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661, PubMed:16434549). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q63424}; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Associated with the cell membrane in resting macrophages and enriched in phagocytic cups and phagosomes after particle internalization. |
| Tissue Location | Expressed in kidney (PubMed:7756356). Not detected in intestine (PubMed:7756356). Highly expressed in macrophages (PubMed:20406817). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity. Hu Y, Shen H, Keep RF, Smith DE, J. Neurochem. 2007 Dec 103 (5): 2058-65. PMID: 17854384
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$ 216.00
Cat# AF2918a
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