|Other Accession||NP_000341.2, 24|
|Calculated MW||255944 Da|
|Other Names||Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein, ABCA4, ABCR|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCA4 (aa1336-49) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.|
|Cellular Location||Membrane; Multi-pass membrane protein Note=Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor|
|Tissue Location||Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells|
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Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. Allocca M, Doria M, Petrillo M, Colella P, Garcia-Hoyos M, Gibbs D, Kim SR, Maguire A, Rex TS, Di Vicino U, Cutillo L, Sparrow JR, Williams DS, Bennett J, Auricchio A. J. Clin. Invest. 2008 May 118 (5): 1955-64. PMID: 18414684.
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