|Application ||IHC, IF, E|
|Other Accession||NP_003719.2, 8633, 22253 (mouse)|
|Calculated MW||103146 Da|
|Other Names||Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C, UNC5C, UNC5H3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UNC5C Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung|
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Provided below are standard protocols that you may find useful for product applications.
Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A. Gastroenterology 2007 Dec 133 (6): 1849-57. PMID: 18054557
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