|Application ||WB, E|
|Other Accession||NP_003589.1, 8463, 21677 (mouse), 294299 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||49243 Da|
|Other Names||Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2, TEAD2, TEF4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ETF-4 / TEAD2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is not expected to cross-react with other TEAD proteins.
Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Molecular and cellular biology 2008 May 28 (10): 3177-89. PMID: 18332127
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