|Application ||WB, E|
|Other Accession||NP_569708.1, NP_987099.1, 170482|
|Calculated MW||25038 Da|
|Other Names||C-type lectin domain family 4 member C, Blood dendritic cell antigen 2, BDCA-2, C-type lectin superfamily member 7, Dendritic lectin, CD303, CLEC4C, BDCA2, CLECSF11, CLECSF7, DLEC, HECL|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC4C / BDCA2 Antibody (Internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BDCA2, CLECSF11, CLECSF7, DLEC, HECL|
|Function||Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform 1 and 2 (NP_569708.1; NP_987099.1).
TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients. Wu P, Wu J, Liu S, Han X, Lu J, Shi Y, Wang J, Lu L, Cao X. Clin Immunol. 2008 Oct;129(1):40-8. Epub 2008 Aug 5. PMID: 18684674
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