|Other Accession||NP_787062.1, 127933, 16589 (mouse), 246332 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||46546 Da|
|Other Names||Serine/threonine-protein kinase Kist, 22.214.171.124, Kinase interacting with stathmin, PAM COOH-terminal interactor protein 2, P-CIP2, U2AF homology motif kinase 1, UHMK1, KIS, KIST|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UHMK1 Antibody (C-Terminus, near) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).|
|Tissue Location||Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells Nakamura S, Okinaka K, Hirano I, Ono T, Sugimoto Y, Shigeno K, Fujisawa S, Shinjo K, Ohnishi K. Leuk Res. 2008 Sep;32(9):1358-65. Epub 2008 Apr 2. PMID: 18384876
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