|Application ||WB, E|
|Other Accession||NP_690902.1, NP_003906.2, 8904|
|Calculated MW||59059 Da|
|Other Names||Copine-1, Copine I, CPNE1, CPN1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Copine 1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha- induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385).|
|Tissue Location||Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize isoform a and b (NP_003906.2; NP_690902.1). Reported variants represent identical protein: NP_690905.1, NP_690902.1, NP_690903.1, NP_690906.1, NP_690904.1, NP_690907.1, NP_690908.1.
Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach. Zhang Y, Gao Q, Duan S, He Y, Sun X, Jiang R, Duan Y, Zhong X, Ge J. Molecular vision 2008 14 : 1028-36. PMID: 18523666
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