|Application ||WB, E|
|Other Accession||NP_110387.1, 53637|
|Calculated MW||41775 Da|
|Other Names||Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8, S1PR5, EDG8|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EDG8 / SPPR1 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.|
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FTY720 modulates human oligodendrocyte progenitor process extension and survival. Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. Annals of neurology 2008 Jan 63 (1): 61-71. PMID: 17918267
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