|Application ||WB, E|
|Other Accession||NP_000288.1, 5311, 18764 (mouse), 498328 (rat)|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||109691 Da|
|Other Names||Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, PKD2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Polycystin 2 / PKD2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).|
|Cellular Location||Cell projection, cilium membrane; Multi- pass membrane protein. Endoplasmic reticulum. Cell membrane. Note=Cell surface and cilium localization requires GANAB.|
|Tissue Location||Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease. Fencl F, Janda J, Bláhová K, Hríbal Z, Stekrová J, Puchmajerová A, Seeman T. Pediatr Nephrol. 2009 May;24(5):983-9. PMID: 19194729
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