|Application ||WB, E|
|Other Accession||NP_003798.2, NP_742011.1, 8740|
|Calculated MW||26350 Da|
|Other Names||Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, CD258, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form, TNFSF14, HVEML, LIGHT|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LIGHT / CD258 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.|
|Cellular Location||Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein Isoform 2: Cytoplasm.|
|Tissue Location||Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_003798.2; NP_742011.1).
LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling Cohavy O, Zhou J, Ware CF, Targan SR J. Immunol. 2005 Jan 174 (2): 646-53 PMID: 15634882
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