|Application ||WB, E|
|Other Accession||NP_002816.1, 5764, 19242 (mouse), 24924 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||18942 Da|
|Other Names||Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Pleiotrophin / PTN Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation.|
|Tissue Location||Osteoblast and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant Kretschmer PJ, Fairhurst JL, Hulmes JD, Popjes ML, Böhlen P, Kovesdi I Biochem Biophys Res Commun. 1993 Apr 30;192(2):420-9. PMID: 8484754
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